Research

Research funded by the Foundation has included:

  • Completion and publication of a prospective study into a novel radiation treatment protocol for feline oral squamous cell carcinoma.
  • Collaborative research with The University of Queensland and The Diamantina Institute into haemangiosarcoma (HSA) in dogs. This work has provided some valuable information about HSA proteomics.

  • A prospective and collaborative study of intra-operative cisplatin for the treatment of canine extremity soft tissue sarcomas.
  • Multiple collaborative retrospective studies with The Veterinary Society of Surgical Oncology including: Vet Surg. 2009 Dec;38(8): Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: a Veterinary Society of Surgical Oncology retrospective study. Farese JP, Kirpensteijn J, Kik M, Bacon NJ, Waltman SS, Seguin B, Kent M, Liptak J, Straw R, Chang MN, Jiang Y, Withrow SJ.
  • Collaborative studies with the Veterinary Cancer Society and the Veterinary Cooperative Oncology Group including: J Am Anim Hosp Assoc. 2009 Jan-Feb;45(1):33-8. Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs. Phillips B, Powers BE, Dernell WS, Straw RC, Khanna C, Hogge GS, Vail DM.
  • The development of pathology guidelines for surgical oncology with involvement in the American College of Veterinary Pathologists' Oncology Committee and this publication: Vet Pathol. 2011 Jan;48(1):19-31. Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology. Kamstock DA, Ehrhart EJ, Getzy DM, Bacon NJ, Rassnick KM, Moroff SD, Liu SM, Straw RC, et al; American College of Veterinary Pathologists' Oncology Committee.
  • The Foundation contributed to the experience in using Toceranib Phosphate (Palladia) during its pre-release by Pfizer Australia and then contributed to the education program of the community and veterinarians in its use to treat dogs with high grade mast cell tumours and other malignancies.
  • Clinical outcome of 42 dogs with scapular tumours treated by scapulectomy: Veterinary Society of Sugical Oncology (VSSO) retrospecitve study (1995-2010). This is a collaborative research paper with the Veterinary Society of Surgical Oncology.
  • Incidence of sterile haemorrhagic cystitis in dogs receiving cyclophosphamide orally for three days without concurrent furosemide as part of a chemotherapeutic treatment for lymphoma: 57 cases (2007-2012). J Am Vet Med Assoc. 2013 Oct 1;243(7):1025-9.
  • Efficacy and toxicity of an accelerated hypofractionated radiation therapy protocol in cats with oral squamous cell carcinoma. Poirier VJ, Kaser-Hotz B, Vail DM, Straw RC. Vet Radiol Ultrasound. 2013 Jan-Feb;54(1):81-8
  • Marvin B.J. Kung, Valérie J. Poirier, Michelle M Dennis, David M. Vail  and Rodney C. Straw. Hypofractionated Radiation Therapy for the treatment of Microscopic Canine Soft Tissue Sarcoma.  Vet and Comp Oncol. 2014 Nov 13.
  • Alok K. Shah, Eunju Choi, Kim-Anh LêCao, David Chen, Benoit Gautier, Caroline O’Leary, Nicholas A. Saunders, Derek Nancarrow, David Whiteman, Helle Bielefeldt-ohmann, Andrew P. Barbour, Rodney Straw, Michelle M. Hill. High Throughput Glycoproteonomics Pipeline for Discovery and Verification of Differentially Glycosylated Serum Proteins as Biomarkers. Preprint.
  • Comparison of clinical and oncologic outcomes between two generations of metal endoprosthesis. A Veterinary Society of Surgical Oncology retrospective study in 45 dogs. Katherine E Mitchell, Marvin Kung, Sarah Dry, Sarah E Boston, Rod C Straw, Nicole P Ehrhart, Stewart D Ryan. Veterinary Surgery 45 (2016) 36–43

The Foundation is currently supporting research into Half Body irradiation as an adjunct to CHOP for dogs with Non-Hodgkin’s lymphoma.  Another project nearing completion is a clinical trial in dogs with osteosarcoma using a novel antimetastatic drug along with surgery, radiation and chemotherapy.  Both these trials are nation wide.

To allow national trials, The Foundation has established the Australian Consortium of Comparative Oncology.  This is a group of veterinary oncologists and scientists around the country who collaborate in clinical trials with the spontaneous animal tumour model.

A close collaboration has also been established with The Diamantina Institute and the Translational Institute of the University of Queensland here in Brisbane.  Another close collaborator is the Centre for Advanced Imaging, CAI.  Also with the University of Queensland, the CAI in collaboration with The Foundation and others were successful in being awarded a grant from the Australian Cancer Research Foundation to provide a PET-CT for the comparative oncology research we are doing.

Our cancer-fighting mission is ongoing and very important.  We needy your help to fund this work.

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